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Mike Keenan

Professor

209 Knapp Hall
phone: 225-578-1708
fax: 225-257-4443

email: mkeenan@agcenter.lsu.edu

PERSONAL PHILOSOPHY
  • I thank Jesus for making a guy like me look smart.
RESEARCH INTERESTS
  • Study of the health effects of the dietary fermentable fiber, resistant starch, which includes molecular effects and the effect on the microbiota. This includes the study of the whole grain and non-whole grain forms of resistant starch and the effects of different dietary levels of fat on fermentation of resistant starch.
RECENT and NOTABLE PUBLICATIONS
    Chapters or essays in books, except for textbook
  • Keenan MJ, Zhou J, Senevirathne RN, Janes M, Martin RJ. Lower gut hormones and health effects associated with consumption of fermentable fibers. In: Nondigestible Carbohydrates and Digestive Health. IFT Press series/Wiley-Blackwell, Ames, IA. Editors, Paeschke TM, Aimutis WR (December 2010; ISBN: 978-0-8138-1762-0).
  • Keenan MJ, Zhou J, Raggio AM, McCutcheon KL, Senevirathne R, Goldsmith F, Janes M, Tulley RT, Shen L, Vidrine K, Williams W, Charrier JA, Ye J, Martin RJ. Mechanisms by which resistant starch produces gut hormones and reduces body fat.Chapter 32:453-466, In: Dietary Fiber and Health, CRC Press: Taylor and Francis Group, Boca Raton, FL, Editors, Cho S, Almeida N (May 2012, ISBN: 13:978-1-4398-9937-3).
    Journal Articles
  • Vidrine K, Ye, J, Martin RJ, McCutcheon KL, Raggio AM, Pelkman C, Durham HA, Zhou J, Semevirathne RS, Williams C, Greenway F, Finley J, Gao Z, Goldsmith F, Keenan MJ (2013) Resistant starch from high amylose maize (HAM-RS2) and dietary butyrate reduce abdominal fat by a different apparent mechanism. Obesity (published online; DOI: 10.1002/oby.20501).
  • Finley JW, Sandlin C, Holliday DL, Keenan MJ, Prinyawiwatkul W, Zheng J (2013) Legumes reduced intestinal fat deposition in the Caenorhabditis elegans model system. Journal of Functional Foods 5:1487-1493
  • Zhou J, Keenan MJ, Fernandez-Kim SO, Pistell PJ, Ingram DK, Li B, Raggio AM, Shen, L, Zhang H, McCutcheon KL, Tulley RT, Blackman MR, Keller JN, Martin RJ (2013) Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents. Molecular Nutrition and Food Research (published online DOI 10.1002/mnfr.201300135).
  • Shen L, Keenan MJ, Zhou J, Martin RJ (2013) Gestational diabetes: Potential of prebiotics intervention. Journal of Pediatric Biochemistry 3:13-21.
  • Charrier JA, Martin RJ, McCutcheon KL, Raggio AM, Goldsmith F, Goita M, Senevirathne RN, Brown IL, Pelkman C, Zhou J, Finley J, Durham HA, Keenan MJ (2013) High fat diet partially attenuates fermentation responses in rats fed resistant starch from high-amylose maize. Obesity (published online; DOI: 10.1002/oby.20362).
  • Keenan MJ, Janes M, Robert J, Martin RJ,Raggio AM, McCutcheon KL, Pelkman C, Tulley RT, Goita M, Durham HA, Zhou J, Senevirathne RN (2013) Reistant starch from high amylose maize (HAM-RS2) reduces body fat and increases gut bacteria in ovariectomized (OVX) rats. Obesity 21:981-984.
  • Tachon S, Zhou J, Keenan MJ, Martin RJ, Marco ML (2013) The intestinal microbiota in aged mice is modulated by dietary resistant starch and correlated to improvements in host responses. FEMS Microbial Ecology 83:299-309.
  • Keenan MJ, Martin RJ, Raggio AM, McCutcheon KL, Brown IL, Birkitt A, Newman SS, Skaf, J, Hegsted M, Tulley RT, Blair E, Zhou J. (2012) A microarray study indicates high-amylose resistant starch increases hormones and improves structure and function of the GI tract. Journal of Nutrigenetics and Nutrigenomics 5:26-44.
  • Zhou J, Keenan MJ, Keller J, Fernandez-Kim SO, Pistell PJ, Tulley RT, Raggio AM, Shen L, Zhang H, Martin RJ, Blackman MR. (2011) Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. Molecular Nutrition and Food Research. 56:515-518.
TEACHING
  • HUEC 3115 Human Nutrition and Metabolism (3 hours)
  • HUEC 4021 Contemporary Topics in Nutrition (1 hour)
  • HUEC 7002 Micronutrients (2 hours). Topics have varied from Bone Health to Nutrigenomics
  • HUEC 7010 Food and Nutrition Seminar (1 hour)
  • HUEC 7011 Current Advances in Food and Nutrition (1-3 hours). Topics have varied from Metabolic integration to Nutrigenomics
RECENT PROFESSIONAL and NOTABLE ACTIVITIES
  • 2010 - Invited to present research on resistant starch at the 9th Vahouny Fiber Conference
  • 2011 - Invited speaker for the University of Illinois-Urbana Nutrition Seminar
  • 2012 - Invited by Ingredion LLC to measure metabolizable energy of a new prebiotic and then present results at a one day meeting with other scientists and company executives
  • 2014 - Invited to present research on resistant starch at the 10th Vahouny Fiber Conference
RESEARCH SUPPORT
    Ongoing Research Support
    Project 1: Effects of resistant starch on insulin sensitivity in rodents.
    2010-2014
    Agency: Industry
    Type: Gift
    Role: PI (10%)
    Goal: Determine effects of resistant starch on fasting insulin and glucose and insulin signaling.
    Amount: $80,000
    Project 2. Identify markers of fermentation of resistant starch in human subjects.
    2011-2014
    Agency: Industry
    Type: Gift
    Role: PI (5%)
    Goal: Analyze fermentation markers in humans fed resistant starch
    Amount: $100,000
    Project 3. Interaction between Sitigliptin and Resistant Starch
    2011-2013
    Agency: Merck
    Type: Contract
    Role: Co-PI (1%)
    Goal: Study the possible interaction between Sitigliptin and Resistant Starch on plasma active GLP-1, plasma glucose and body weight and body fat
    Amount: $137,550
    Project 4. Role of slowly digestible starch in diabetes risk factors in pre-diabetic people.
    2012-2016
    Agency: NIH
    Type: Grant
    Role: Other faculty (5%)
    Goal: Investigate the effects of slowly digestible starch in pre-diabetic people
    Amount: $3,203,509
    Project 5. Metabolizable Energy
    2012-2013
    Agency: Industry
    Type: Grant
    Role: Multiple PI (10%)
    Goal: Propietary
    Amount: $30,000
    Project 6. Use of three bioactive components, whole-grain, resistant starch and moderate dietary fat, to improve gut health and boost immune function.
    2013-2016
    Agency: USDA NIFA
    Type: Grant
    Role: PI (10%)
    Goal: Compare whole-grain resistant starch vs. non-whole-grain in moderate fat vs. high fat diets
    Amount: $499,344
revised: 10-Mar-2017 10:20